Combining health register data and biobank data

- Statistical Journal of the IAOS: Journal of the International Association for Official Statistics
Author/s: -Gissler, Mika -Surcel, Heljä-Marja
Journal: Statistical Journal of the IAOS: Journal of the International Association for Official Statistics
Year: 2012
Volume: 28
Issue: 1
Pages: 53-58
Abstract:

The Finnish Health Information System is based on detailed individual level information. All register-based sources include a personal identification number, which can be used for data linkages. In this article, the possibilities and problems in combining biobank information donated by women in early pregnancy and collected by the Finnish Maternity Cohort (FMC) to nationwide health registers are described. The FMC biobank data can be combined to Medical Birth Register (since 1987) and Register on Congenital Malformations (1963) to get additional information on mothers’ and their offspring’s background, health and care during pregnancy, and birth. Cancer Register (1953), Cause-of-Death Register (1969), Hospital Discharge Register (1969), and Register on Reimbursed Prescribed Medicine (1994) are the most used health registers in studying mothers’ and their offspring’s subsequent health. Combination of data from Central Population Register (1973) enables family studies on subsequent generations and siblings. The main problems in using biobank material are limited availability of blood sera, the risk of decreased sample quality, the ideal selection of study plans, and the complex process to get permission to use the data and to form it. The use of register data is limited to the existing data with good quality. The archiving and sharing of completed biobank analyses is recommended.

URL: http://dx.doi.org/10.3233/SJI-2012-0744