Informed Consent in the Genomics Era

- PLoS Medicine
Author/s: -Mascalzoni, Deborah
Journal: PLoS Medicine
Year: 2008
Volume: 5
Issue: 9
Pages: 0001
Start Page: 0001

Since the Nuremberg trials, informed consent (IC) has been recognized as a basic ethical requirement for research involving human participants [1] (Table 1). Such consent encompasses two distinct elements: (1) researchers communicate detailed information about study procedures, outcomes, risks, and benefits for the participating individual or community, and (2) after understanding and careful consideration, the participants consent to take part under these conditions. However, the suitability of IC for genomic studies has been recently challenged [2,3]. Because the research protocol for such studies may evolve over time, the condition in IC of providing detailed information for a well-defined protocol is not easily satisfied.